Minimal-change glomerulopathy and glomerular visceral epithelial hyperplasia associated with alpha-interferon therapy for cutaneous T-cell lymphoma

A. Traynor*, T. Kuzel, E. Samuelson, Y. Kanwar

*Corresponding author for this work

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

A 44-year-old man was diagnosed with cutaneous T-cell lymphoma characterized by a proliferation of CD4-positive cells. In response to α-interferon therapy, he experienced rapid regression of his cutaneous disease. This improvement was associated with development of renal failure, characterized by nephrotic-range proteinuria with interstitial nephritis and minimal-change nephropathy. The remarkable finding of renal biopsy was marked proliferation of visceral epithelial cells (podocytes). Renal disease improved significantly in response to discontinuation of interferon and initiation of prednisone therapy. Nephrotic range proteinuria regressed, but never completely resolved. This case is illustrative of the probable role for lymphokine-mediated nephrotoxicity in the setting of lymphoproliferative disease.

Original languageEnglish (US)
Pages (from-to)94-100
Number of pages7
JournalNephron
Volume67
Issue number1
StatePublished - Jan 1 1994

Keywords

  • Epithelial hyperplasia
  • Interferon
  • Lymphoma
  • Minimal-change disease

ASJC Scopus subject areas

  • Nephrology

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