Minimal data reporting standards for serological testing for histocompatibility

Nicole M. Valenzuela*, Medhat Askar, Sebastiaan Heidt, Peter Jindra, Abeer Madbouly, David Pinelli, Annette Jackson, Luis G. Hidalgo

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Histocompatibility testing, and HLA antibody screening in particular, varies in practice among laboratories. Currently, standards are lacking regarding the reporting of testing methods in publications. It is essential that scientific methods are rigorously and transparently described upon publication, so that results can be accurately interpreted and independently corroborated. Additionally, this would allow work groups to compile diverse data to achieve clinically significant conclusions from meta-analyses. These efforts are hindered when there is a paucity of method descriptions and where variability in serum treatment, protocol modifications, and assay thresholds affecting assay interpretation are known to exist. Thus, the ASHI Science and Technology Initiatives Committee (ASHI STIC) undertook the task of formulating recommendations for reporting HLA antibody testing by solid phase assays, and the associated HLA typing required for interpretation, in scientific publications. Herein we put forth standards for minimum information about HLA antibody testing methods reported in histocompatibility publications.

Original languageEnglish (US)
Pages (from-to)865-868
Number of pages4
JournalHuman Immunology
Volume79
Issue number12
DOIs
StatePublished - Dec 2018

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Keywords

  • HLA antibodies
  • Histocompatibility
  • Serology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Valenzuela, N. M., Askar, M., Heidt, S., Jindra, P., Madbouly, A., Pinelli, D., Jackson, A., & Hidalgo, L. G. (2018). Minimal data reporting standards for serological testing for histocompatibility. Human Immunology, 79(12), 865-868. https://doi.org/10.1016/j.humimm.2018.08.008