Minimal Rev-response element for type 1 human immunodeficiency virus

Xiaojian Huang, Thomas J. Hope, Barbara L. Bond, David Mcdonald, Kim Grahl, Tristram G. Parslow*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Rev protein regulates nuclear export of viral mRNAs that contain a 240-base RNA sequence termed the Rev-response element (RRE). We demonstrate that an 88-base truncated RRE encompassing a known Rev binding site can mediate Rev responsiveness in vivo. Two tandem copies of this mutant function as efficiently as the full-length RRE.

Original languageEnglish (US)
Pages (from-to)2131-2134
Number of pages4
JournalJournal of virology
Volume65
Issue number4
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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