Minimally invasive ablative approaches in the treatment of renal cell carcinoma.

Nicolette Janzen*, Amnon Zisman, Allan J. Pantuck, Kent Perry, Peter Schulam, Arie S. Belldegrun

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Ablative techniques for the treatment of renal cell carcinoma (RCC) are an extension of nephron-sparing surgery and include cryoablation, radiofrequency ablation (RFA), and high-intensity focused ultrasound (HIFU). Although experimental, these are evolving treatment modalities. The widespread use of computed tomography scans, ultrasound, and magnetic resonance imaging caused an increase in the diagnosis rate of small renal masses amenable to nephron-sparing surgery. The same imaging modalities permit interactive monitoring both during the delivery of ablative measures and at postoperative follow-up. Cryosurgery is the most studied of the ablative approaches, and clinical studies have demonstrated promising short-term results and a remarkable safety profile. Long-term studies, however, are needed in order to determine the appropriate selection criteria and to confirm a response as durable as that for partial and radical nephrectomy. More data are needed to evaluate the efficacy of RFA. Currently, preclinical results with HIFU do not justify its use for treating RCC in humans.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalCurrent urology reports
Issue number1
StatePublished - Feb 2002

ASJC Scopus subject areas

  • Urology


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