Minireview

Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor

Daniel J. Bernard, Stacey C. Chapman, Teresa K Woodruff*

*Corresponding author for this work

Research output: Contribution to journalShort survey

43 Citations (Scopus)

Abstract

Betaglycan (the TGFβ type III receptor) and InhBP/p120 (a membrane-tethered proteoglycan) were recently identified as putative inhibin receptors. Here, we review the current state of knowledge regarding these two proteins with respect to their potential roles in inhibin biology. Importantly, neither protein appears to satisfy all of the criteria required for classification as a bona fide inhibin receptor. Betaglycan does not appear to be expressed in pituitary gonadotropes, the primary target of circulating inhibins, and InhBP/p120 does not bind inhibins in conventional receptor binding assays. While both proteins appear capable of promoting Inhibin-mediated antagonism of activin signaling, neither appears to generate inhibin-specific intracellular signals. Recently, additional inhibin binding proteins were identified in inhibin target tissues, including pituitary and Leydig cells. Characterization of these proteins, coupled with ongoing investigations of betaglycan and InhBP/p120, will lead to a clearer understanding of mechanisms of inhibin action.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalMolecular Endocrinology
Volume16
Issue number2
DOIs
StatePublished - Jan 1 2002

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Inhibins
Carrier Proteins
Proteins
betaglycan
Activins
Leydig Cells
Proteoglycans

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

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title = "Minireview: Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor",
abstract = "Betaglycan (the TGFβ type III receptor) and InhBP/p120 (a membrane-tethered proteoglycan) were recently identified as putative inhibin receptors. Here, we review the current state of knowledge regarding these two proteins with respect to their potential roles in inhibin biology. Importantly, neither protein appears to satisfy all of the criteria required for classification as a bona fide inhibin receptor. Betaglycan does not appear to be expressed in pituitary gonadotropes, the primary target of circulating inhibins, and InhBP/p120 does not bind inhibins in conventional receptor binding assays. While both proteins appear capable of promoting Inhibin-mediated antagonism of activin signaling, neither appears to generate inhibin-specific intracellular signals. Recently, additional inhibin binding proteins were identified in inhibin target tissues, including pituitary and Leydig cells. Characterization of these proteins, coupled with ongoing investigations of betaglycan and InhBP/p120, will lead to a clearer understanding of mechanisms of inhibin action.",
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Minireview : Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor. / Bernard, Daniel J.; Chapman, Stacey C.; Woodruff, Teresa K.

In: Molecular Endocrinology, Vol. 16, No. 2, 01.01.2002, p. 207-212.

Research output: Contribution to journalShort survey

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