Minireview: Mas-related G protein-coupled receptor X2 activation by therapeutic drugs

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11 Scopus citations


Symptoms that resemble allergic reactions, such as pruritus, flushing, and hypotension, are common side effects of therapeutic drugs. In a true allergic reaction, Immunoglobulin E (IgE) antibodies recognize the drug and trigger mediator release from mast cells through cross-linking of IgE receptors. However, many drugs can bypass this pathway and can activate mast cells directly through MRGPRX2, a G protein-coupled receptor that responds to a wide range of small molecules, peptides, and proteins that have little in common except for a net positive charge. This review will provide an overview of MRGPRX2, including its expression pattern, studies of its pharmacology, and its orthologs. It also will review evidence for MRGPRX2 activation by many drugs closely associated with these reactions.

Original languageEnglish (US)
Article number135746
JournalNeuroscience Letters
StatePublished - Apr 23 2021


  • Anaphylaxis
  • Flare
  • IgE-independent
  • Immediate hypersensitivity
  • Mast cells
  • Mrgprb2
  • Pruritus
  • Pseudo-allergic
  • Wheal

ASJC Scopus subject areas

  • Neuroscience(all)


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