Minireview: Metabolism of female reproduction: Regulatory mechanisms and clinical implications

Emre Seli, Elnur Babayev, Stephen C. Collins, Gabor Nemeth, Tamas L. Horvath

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Female fertility is highly dependent on successful regulation of energy metabolism. Central processes in the hypothalamus monitor the metabolic state of the organism and, together with metabolic hormones, drive the peripheral availability of energy for cellular functions. In the ovary, the oocyte and neighboring somatic cells of the follicle work in unison to achieve successful metabolism of carbohydrates, amino acids, and lipids. Metabolic disturbances such as anorexia nervosa, obesity, and diabetes mellitus have clinically important consequences on human reproduction. In this article, we review the metabolic determinants of female reproduction and their role in infertility.

Original languageEnglish (US)
Pages (from-to)790-804
Number of pages15
JournalMolecular Endocrinology
Volume28
Issue number6
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology

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