Minor physical anomalies are not increased in the offspring of mothers with systemic lupus erythematosus

P. N. Bonaminio, Raye-Ann O de Regnier, E. Chang, N. Day, S. Manzi, Rosalind Ramsey-Goldman*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objective: To determine the incidence and type of minor physical anomalies (MPAs) in infants born to mothers with systemic lupus erythematosus (SLE). Methods: Each trimester, pregnant women with SLE were assessed for disease activity, prescribed drug use, and exposure to tobacco, alcohol, and illicit drugs through a self reported questionnaire. Infant examinations were performed on 30/39 (77%) live births in women with SLE and the incidence of MPAs determined. Results: 2/30 (7%) patients had three or more MPAs; 4 (13%) had two; 7 (23%) had one; and 17 (57%) had none. One in three women reported alcohol, tobacco, and illicit drug use. Facial anomalies were the most common MPAs. The relative risk and 95% confidence interval for any MPA were 2.05 (0.99 to 4.20) for tobacco use; 1.95 (0.92 to 4.11) for alcohol use; 1.36 (0.165 to 11.23) for maternal disease flare; 0.63 (0.27 to 1.47) for prednisone use; and 0.72 (0.21 to 2.44) for aspirin use. Conclusion: 13/30 (43%) infants had minor anomalies-a similar incidence to that of the general population. Counselling for preventable self reported exposure is advisable in addition to counselling specifically for lupus management during pregnancy.

Original languageEnglish (US)
Pages (from-to)246-248
Number of pages3
JournalAnnals of the Rheumatic Diseases
Volume65
Issue number2
DOIs
StatePublished - Feb 1 2006

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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