@article{f6cc20f1b23741efa8575f3eaa323892,
title = "miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells",
abstract = "DC-SIGN+ mo-DCs play important roles in bacterial infections and inflammatory diseases, but the factors regulating differentiation and activation remain poorly defined. Lim et al. show that miR-181a simultaneously fine-tunes DC-SIGN+ mo-DC differentiation/activation by promoting ERK-MAPK signaling, which sustains DC-SIGN expression and limits its responsiveness to TLR4 triggering and inflammatory stimuli.",
keywords = "DC-SIGN, DC-SIGN mo-DC, inflammation, miR-181a, mo-DC, monocyte-derived, terminal mo-DC differentiation, ulcerative colitis",
author = "Lim, {Clarice X.} and Bernett Lee and Olivia Geiger and Christina Passegger and Michaela Beitzinger and Johann Romberger and Anika Stracke and Christoph H{\"o}genauer and Anton Stift and Heribert Stoiber and Michael Poidinger and Armin Zebisch and Gunter Meister and Adam Williams and Flavell, {Richard A.} and Jorge Henao-Mejia and Herbert Strobl",
note = "Funding Information: We thank D. Printz (St. Anna Children's Hospital) and V. Zrim (ZMF Flow Cytometry Facility) for cell sorting and B. Rinner and J. Obers for Luminex measurement. We also thank Mariana Vazquez Strauss for designing the graphical abstract. This work was supported by grants from the Austrian Science Fund (FWF, P25720) to H. Strobl and PhD program W1212 “Inflammation and Immunity” to C.X.L. We are also thankful for support from the Institute of Immunology, Medical University of Vienna, and the lab of R.A.F. who is supported by the Howard Hughes Medical Institute. C.X.L. designed and performed experiments, analyzed the data, and wrote the manuscript. B.L. performed microarray analyses. O.G. M.B. C.P. A.S. and J.R. assisted in performing some experiments. C.H. and A.S. provided samples and clinical expertise. A.Z. M.P. H.Stoiber, and G.M. gave advice in design and result interpretation of some experiments. R.A.F. J.H.-M. and A.W. provided mice and supervised some experiments. H. Strobl supervised the project, secured funding, and co-wrote the manuscript. The authors declare no competing interests. Funding Information: We thank D. Printz (St. Anna Children{\textquoteright}s Hospital) and V. Zrim (ZMF Flow Cytometry Facility) for cell sorting and B. Rinner and J. Obers for Luminex measurement. We also thank Mariana Vazquez Strauss for designing the graphical abstract. This work was supported by grants from the Austrian Science Fund (FWF, P25720 ) to H. Strobl and PhD program W1212 “Inflammation and Immunity” to C.X.L. We are also thankful for support from the Institute of Immunology, Medical University of Vienna, and the lab of R.A.F., who is supported by the Howard Hughes Medical Institute . Publisher Copyright: {\textcopyright} 2020",
year = "2020",
month = mar,
day = "17",
doi = "10.1016/j.celrep.2020.02.077",
language = "English (US)",
volume = "30",
pages = "3793--3805.e5",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",
}