MiR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma

Richard Flavin; Paul Smyth; Ciara Barrett; S. Russell; Hannah Wen; Jianjun Wei; Alex Laios; Sharon O'Toole; M. Ring; K. Denning; J. Li; S. Aherne; D. Sammarae; N. A. Aziz; A. Alhadi; Sephen P. Finn; M. Loda; B. Sheppard; Orla Sheils; John J. O'Leary

doi:10.1111/IGC.0b013e3181a48cf9

MiR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma

Richard Flavin^*, Paul Smyth, Ciara Barrett, S. Russell, Hannah Wen, Jianjun Wei, Alex Laios, Sharon O'Toole, M. Ring, K. Denning, J. Li, S. Aherne, D. Sammarae, N. A. Aziz, A. Alhadi, Sephen P. Finn, M. Loda, B. Sheppard, Orla Sheils, John J. O'Leary

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Micro-RNAs are a group of small noncoding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature micro-RNAs in human cancers. We characterized the alteration in expression of miR-29b in ovarian serous carcinoma. miR-29b expression was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on a set of 50 formalin-fixed, paraffin-embedded ovarian serous carcinoma samples. Protein expression of p53, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, and insulinlike growth factor 1 was quantified in the corresponding tissue microarray. The expression profile of miR-29b was correlated with clinicopathological and patient survival data. We provide definitive evidence that miR-29b is down-regulated in a significant proportion of ovarian serous carcinomas and is associated with specific clinicopathological features, most notably high miR-29b expression being associated with reduced disease-free survival.

Original language	English (US)
Pages (from-to)	641-647
Number of pages	7
Journal	International Journal of Gynecological Cancer
Volume	19
Issue number	4
DOIs	https://doi.org/10.1111/IGC.0b013e3181a48cf9
State	Published - May 2009

Keywords

Biomarkers
Micro-RNA
Ovarian serous carcinoma

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/IGC.0b013e3181a48cf9

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Flavin, R., Smyth, P., Barrett, C., Russell, S., Wen, H., Wei, J., Laios, A., O'Toole, S., Ring, M., Denning, K., Li, J., Aherne, S., Sammarae, D., Aziz, N. A., Alhadi, A., Finn, S. P., Loda, M., Sheppard, B., Sheils, O., & O'Leary, J. J. (2009). MiR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma. International Journal of Gynecological Cancer, 19(4), 641-647. https://doi.org/10.1111/IGC.0b013e3181a48cf9

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title = "MiR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma",

abstract = "Micro-RNAs are a group of small noncoding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature micro-RNAs in human cancers. We characterized the alteration in expression of miR-29b in ovarian serous carcinoma. miR-29b expression was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on a set of 50 formalin-fixed, paraffin-embedded ovarian serous carcinoma samples. Protein expression of p53, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, and insulinlike growth factor 1 was quantified in the corresponding tissue microarray. The expression profile of miR-29b was correlated with clinicopathological and patient survival data. We provide definitive evidence that miR-29b is down-regulated in a significant proportion of ovarian serous carcinomas and is associated with specific clinicopathological features, most notably high miR-29b expression being associated with reduced disease-free survival.",

keywords = "Biomarkers, Micro-RNA, Ovarian serous carcinoma",

author = "Richard Flavin and Paul Smyth and Ciara Barrett and S. Russell and Hannah Wen and Jianjun Wei and Alex Laios and Sharon O'Toole and M. Ring and K. Denning and J. Li and S. Aherne and D. Sammarae and Aziz, {N. A.} and A. Alhadi and Finn, {Sephen P.} and M. Loda and B. Sheppard and Orla Sheils and O'Leary, {John J.}",

year = "2009",

month = may,

doi = "10.1111/IGC.0b013e3181a48cf9",

language = "English (US)",

volume = "19",

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journal = "International Journal of Gynecological Cancer",

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Flavin, R, Smyth, P, Barrett, C, Russell, S, Wen, H, Wei, J, Laios, A, O'Toole, S, Ring, M, Denning, K, Li, J, Aherne, S, Sammarae, D, Aziz, NA, Alhadi, A, Finn, SP, Loda, M, Sheppard, B, Sheils, O & O'Leary, JJ 2009, 'MiR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma', International Journal of Gynecological Cancer, vol. 19, no. 4, pp. 641-647. https://doi.org/10.1111/IGC.0b013e3181a48cf9

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AU - Flavin, Richard

AU - Smyth, Paul

AU - Barrett, Ciara

AU - Russell, S.

AU - Wen, Hannah

AU - Wei, Jianjun

AU - Laios, Alex

AU - O'Toole, Sharon

AU - Ring, M.

AU - Denning, K.

AU - Li, J.

AU - Aherne, S.

AU - Sammarae, D.

AU - Aziz, N. A.

AU - Alhadi, A.

AU - Finn, Sephen P.

AU - Loda, M.

AU - Sheppard, B.

AU - Sheils, Orla

AU - O'Leary, John J.

PY - 2009/5

Y1 - 2009/5

N2 - Micro-RNAs are a group of small noncoding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature micro-RNAs in human cancers. We characterized the alteration in expression of miR-29b in ovarian serous carcinoma. miR-29b expression was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on a set of 50 formalin-fixed, paraffin-embedded ovarian serous carcinoma samples. Protein expression of p53, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, and insulinlike growth factor 1 was quantified in the corresponding tissue microarray. The expression profile of miR-29b was correlated with clinicopathological and patient survival data. We provide definitive evidence that miR-29b is down-regulated in a significant proportion of ovarian serous carcinomas and is associated with specific clinicopathological features, most notably high miR-29b expression being associated with reduced disease-free survival.

AB - Micro-RNAs are a group of small noncoding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature micro-RNAs in human cancers. We characterized the alteration in expression of miR-29b in ovarian serous carcinoma. miR-29b expression was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on a set of 50 formalin-fixed, paraffin-embedded ovarian serous carcinoma samples. Protein expression of p53, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, and insulinlike growth factor 1 was quantified in the corresponding tissue microarray. The expression profile of miR-29b was correlated with clinicopathological and patient survival data. We provide definitive evidence that miR-29b is down-regulated in a significant proportion of ovarian serous carcinomas and is associated with specific clinicopathological features, most notably high miR-29b expression being associated with reduced disease-free survival.

KW - Biomarkers

KW - Micro-RNA

KW - Ovarian serous carcinoma

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JF - International Journal of Gynecological Cancer

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ER -

MiR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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