MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia

Veena S. Patel; Sinead Kelly; Carrie Wright; Cota Navin Gupta; Alejandro Arias-Vasquez; Nora Perrone-Bizzozero; Stefan Ehrlich; Lei Wang; Juan R. Bustillo; Derek Morris; Aiden Corvin; Dara M. Cannon; Colm McDonald; Gary Donohoe; Vince D. Calhoun; Jessica A. Turner

doi:10.1016/j.neulet.2015.06.039

MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia

Veena S. Patel, Sinead Kelly, Carrie Wright, Cota Navin Gupta, Alejandro Arias-Vasquez, Nora Perrone-Bizzozero, Stefan Ehrlich, Lei Wang, Juan R. Bustillo, Derek Morris, Aiden Corvin, Dara M. Cannon, Colm McDonald, Gary Donohoe, Vince D. Calhoun, Jessica A. Turner^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of individuals with schizophrenia and healthy controls (n = 841). Although the volumes were overall reduced relative to healthy controls, for individuals with schizophrenia the homozygous MIR137HGrv risk genotype was associated with attenuated reduction of mid-posterior corpus callosum volume (p = 0.001), along with trend-level effects in the adjacent central and posterior corpus callosum. These findings are unique in the literature and remain robust after analysis in ethnically homogenous and single-scanner subsets of the larger sample. Thus, our study suggests that the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder.

Original language	English (US)
Pages (from-to)	44-49
Number of pages	6
Journal	Neuroscience Letters
Volume	602
DOIs	https://doi.org/10.1016/j.neulet.2015.06.039
State	Published - Aug 8 2015

Funding

This work was supported by the National Institutes of Health (grant numbers 5R01MH094524-03 to VDC and JAT, R01MH084898-01A1 to JRB, P50 MH071616 , R01MH056584 , 1R01 MH084803 to LW, and 1U01 MH097435 to LW and JAT); the United States Department of Energy (grant number DE-FG02-99ER62764 ); the Science Foundation Ireland (grand number SFI 12.IP.1359 ); the Irish Health Research Board (grant numbers HRA_POR/2011/100 , HRA_POR/2012/54 ); and the Wellcome Trust (grant number 72894/2/03/Z ).

Keywords

Corpus callosum
MIR137
MicroRNA-137
Multi-site
Schizophrenia
Subcortical volume

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2015.06.039

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Patel, V. S., Kelly, S., Wright, C., Gupta, C. N., Arias-Vasquez, A., Perrone-Bizzozero, N., Ehrlich, S., Wang, L., Bustillo, J. R., Morris, D., Corvin, A., Cannon, D. M., McDonald, C., Donohoe, G., Calhoun, V. D., & Turner, J. A. (2015). MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia. Neuroscience Letters, 602, 44-49. https://doi.org/10.1016/j.neulet.2015.06.039

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title = "MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia",

abstract = "Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of individuals with schizophrenia and healthy controls (n = 841). Although the volumes were overall reduced relative to healthy controls, for individuals with schizophrenia the homozygous MIR137HGrv risk genotype was associated with attenuated reduction of mid-posterior corpus callosum volume (p = 0.001), along with trend-level effects in the adjacent central and posterior corpus callosum. These findings are unique in the literature and remain robust after analysis in ethnically homogenous and single-scanner subsets of the larger sample. Thus, our study suggests that the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder.",

keywords = "Corpus callosum, MIR137, MicroRNA-137, Multi-site, Schizophrenia, Subcortical volume",

author = "Patel, \{Veena S.\} and Sinead Kelly and Carrie Wright and Gupta, \{Cota Navin\} and Alejandro Arias-Vasquez and Nora Perrone-Bizzozero and Stefan Ehrlich and Lei Wang and Bustillo, \{Juan R.\} and Derek Morris and Aiden Corvin and Cannon, \{Dara M.\} and Colm McDonald and Gary Donohoe and Calhoun, \{Vince D.\} and Turner, \{Jessica A.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd.",

year = "2015",

month = aug,

day = "8",

doi = "10.1016/j.neulet.2015.06.039",

language = "English (US)",

volume = "602",

pages = "44--49",

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Patel, VS, Kelly, S, Wright, C, Gupta, CN, Arias-Vasquez, A, Perrone-Bizzozero, N, Ehrlich, S, Wang, L, Bustillo, JR, Morris, D, Corvin, A, Cannon, DM, McDonald, C, Donohoe, G, Calhoun, VD & Turner, JA 2015, 'MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia', Neuroscience Letters, vol. 602, pp. 44-49. https://doi.org/10.1016/j.neulet.2015.06.039

TY - JOUR

T1 - MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia

AU - Patel, Veena S.

AU - Kelly, Sinead

AU - Wright, Carrie

AU - Gupta, Cota Navin

AU - Arias-Vasquez, Alejandro

AU - Perrone-Bizzozero, Nora

AU - Ehrlich, Stefan

AU - Wang, Lei

AU - Bustillo, Juan R.

AU - Morris, Derek

AU - Corvin, Aiden

AU - Cannon, Dara M.

AU - McDonald, Colm

AU - Donohoe, Gary

AU - Calhoun, Vince D.

AU - Turner, Jessica A.

PY - 2015/8/8

Y1 - 2015/8/8

N2 - Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of individuals with schizophrenia and healthy controls (n = 841). Although the volumes were overall reduced relative to healthy controls, for individuals with schizophrenia the homozygous MIR137HGrv risk genotype was associated with attenuated reduction of mid-posterior corpus callosum volume (p = 0.001), along with trend-level effects in the adjacent central and posterior corpus callosum. These findings are unique in the literature and remain robust after analysis in ethnically homogenous and single-scanner subsets of the larger sample. Thus, our study suggests that the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder.

AB - Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of individuals with schizophrenia and healthy controls (n = 841). Although the volumes were overall reduced relative to healthy controls, for individuals with schizophrenia the homozygous MIR137HGrv risk genotype was associated with attenuated reduction of mid-posterior corpus callosum volume (p = 0.001), along with trend-level effects in the adjacent central and posterior corpus callosum. These findings are unique in the literature and remain robust after analysis in ethnically homogenous and single-scanner subsets of the larger sample. Thus, our study suggests that the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder.

KW - Corpus callosum

KW - MIR137

KW - MicroRNA-137

KW - Multi-site

KW - Schizophrenia

KW - Subcortical volume

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SN - 0304-3940

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SP - 44

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JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia

Abstract

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Keywords

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