Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera

Susama Verma; Katia Cikurel; Igor J. Koralnik; Susan Morgello; Charlotte Cunningham-Rundles; Zelig R. Weinstein; Christine Bergmann; David M. Simpson

doi:10.1086/520514

Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera

Susama Verma, Katia Cikurel, Igor J. Koralnik, Susan Morgello, Charlotte Cunningham-Rundles, Zelig R. Weinstein, Christine Bergmann, David M. Simpson^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.

Original language	English (US)
Pages (from-to)	709-711
Number of pages	3
Journal	Journal of Infectious Diseases
Volume	196
Issue number	5
DOIs	https://doi.org/10.1086/520514
State	Published - Sep 1 2007

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

UN SDGs

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10.1086/520514

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title = "Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera",

abstract = "Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.",

author = "Susama Verma and Katia Cikurel and Koralnik, {Igor J.} and Susan Morgello and Charlotte Cunningham-Rundles and Weinstein, {Zelig R.} and Christine Bergmann and Simpson, {David M.}",

note = "Funding Information: Received 11 August 2006; accepted 15 February 2007; electronically published 13 July 2007. Potential conflicts of interest: none reported. Financial support: Public Health Service (grants R01 NS/AI 041198 and NS 047029 to I.J.K. and NS002253 to D.M.S.); Ellen R. Cavallo Research Fund; National Institutes of Health (grant R24MH59724 to S.M. and D.M.S.). Reprints or correspondence: Dr. David M. Simpson, Mount Sinai Medical Center, One Gustave L. Levy Pl., Box 1052, Annenberg, 2nd Fl., New York, NY 10029-6574 (david.simpson@ mssm.edu).",

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AU - Verma, Susama

AU - Cikurel, Katia

AU - Koralnik, Igor J.

AU - Morgello, Susan

AU - Cunningham-Rundles, Charlotte

AU - Weinstein, Zelig R.

AU - Bergmann, Christine

AU - Simpson, David M.

N1 - Funding Information: Received 11 August 2006; accepted 15 February 2007; electronically published 13 July 2007. Potential conflicts of interest: none reported. Financial support: Public Health Service (grants R01 NS/AI 041198 and NS 047029 to I.J.K. and NS002253 to D.M.S.); Ellen R. Cavallo Research Fund; National Institutes of Health (grant R24MH59724 to S.M. and D.M.S.). Reprints or correspondence: Dr. David M. Simpson, Mount Sinai Medical Center, One Gustave L. Levy Pl., Box 1052, Annenberg, 2nd Fl., New York, NY 10029-6574 (david.simpson@ mssm.edu).

PY - 2007/9/1

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N2 - Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.

AB - Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.

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Mirtazapine in progressive multifocal leukoencephalopathy associated with polycythemia vera

Abstract

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