Misinterpretation of a calvert-derived formula leading to carboplatin overdose in two children

Robert I. Liem; Meghan A. Higman; Allen R. Chen; Robert J. Arceci

doi:10.1097/00043426-200310000-00017

Misinterpretation of a calvert-derived formula leading to carboplatin overdose in two children

Robert I. Liem, Meghan A. Higman, Allen R. Chen, Robert J. Arceci^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Carboplatin is currently recommended to be dosed according to renal function. In adults, dosing by the Calvert formula is based on evidence that carboplatin clearance closely parallels glomerular filtration rate. Several studies have attempted to validate the Calvert formula and its derivations in pediatrics, but no final consensus has been achieved. As a result, different versions of the original formula exist in the pediatric literature. Other factors may also contribute to confusion when applying the formula to young patients, including the manner in which renal function is measured and reported. We describe how misinterpretation of the Calvert formula resulted in carboplatin overdosing in 2 pediatric patients with high-risk neuroblastoma undergoing peripheral blood stem cell transplantation. Measures to avoid such errors have been instituted.

Original language	English (US)
Pages (from-to)	818-821
Number of pages	4
Journal	Journal of Pediatric Hematology/Oncology
Volume	25
Issue number	10
DOIs	https://doi.org/10.1097/00043426-200310000-00017
State	Published - Oct 1 2003

Keywords

Calvert
Carboplatin
Neuroblastoma
Transplantation

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Oncology
Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00043426-200310000-00017

Cite this

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abstract = "Carboplatin is currently recommended to be dosed according to renal function. In adults, dosing by the Calvert formula is based on evidence that carboplatin clearance closely parallels glomerular filtration rate. Several studies have attempted to validate the Calvert formula and its derivations in pediatrics, but no final consensus has been achieved. As a result, different versions of the original formula exist in the pediatric literature. Other factors may also contribute to confusion when applying the formula to young patients, including the manner in which renal function is measured and reported. We describe how misinterpretation of the Calvert formula resulted in carboplatin overdosing in 2 pediatric patients with high-risk neuroblastoma undergoing peripheral blood stem cell transplantation. Measures to avoid such errors have been instituted.",

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AU - Liem, Robert I.

AU - Higman, Meghan A.

AU - Chen, Allen R.

AU - Arceci, Robert J.

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Y1 - 2003/10/1

N2 - Carboplatin is currently recommended to be dosed according to renal function. In adults, dosing by the Calvert formula is based on evidence that carboplatin clearance closely parallels glomerular filtration rate. Several studies have attempted to validate the Calvert formula and its derivations in pediatrics, but no final consensus has been achieved. As a result, different versions of the original formula exist in the pediatric literature. Other factors may also contribute to confusion when applying the formula to young patients, including the manner in which renal function is measured and reported. We describe how misinterpretation of the Calvert formula resulted in carboplatin overdosing in 2 pediatric patients with high-risk neuroblastoma undergoing peripheral blood stem cell transplantation. Measures to avoid such errors have been instituted.

AB - Carboplatin is currently recommended to be dosed according to renal function. In adults, dosing by the Calvert formula is based on evidence that carboplatin clearance closely parallels glomerular filtration rate. Several studies have attempted to validate the Calvert formula and its derivations in pediatrics, but no final consensus has been achieved. As a result, different versions of the original formula exist in the pediatric literature. Other factors may also contribute to confusion when applying the formula to young patients, including the manner in which renal function is measured and reported. We describe how misinterpretation of the Calvert formula resulted in carboplatin overdosing in 2 pediatric patients with high-risk neuroblastoma undergoing peripheral blood stem cell transplantation. Measures to avoid such errors have been instituted.

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KW - Neuroblastoma

KW - Transplantation

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Misinterpretation of a calvert-derived formula leading to carboplatin overdose in two children

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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