Mitochondria as a therapeutic target in heart failure

Marina Bayeva, Mihai Gheorghiade, Hossein Ardehali*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

206 Scopus citations

Abstract

Heart failure is a pressing public health problem with no curative treatment currently available. The existing therapies provide symptomatic relief, but are unable to reverse molecular changes that occur in cardiomyocytes. The mechanisms of heart failure are complex and multiple, but mitochondrial dysfunction appears to be a critical factor in the development of this disease. Thus, it is important to focus research efforts on targeting mitochondrial dysfunction in the failing heart to revive the myocardium and its contractile function. This review highlights the 3 promising areas for the development of heart failure therapies, including mitochondrial biogenesis, mitochondrial oxidative stress, and mitochondrial iron handling. Moreover, the translational potential of compounds targeting these pathways is discussed.

Original languageEnglish (US)
Pages (from-to)599-610
Number of pages12
JournalJournal of the American College of Cardiology
Volume61
Issue number6
DOIs
StatePublished - Feb 12 2013

Keywords

  • cardiomyocytes
  • heart failure
  • mitochondria

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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