Mitochondria-ER Pas de Deux Controls Memory T Cell Function

Elizabeth M. Steinert; Navdeep S. Chandel

doi:10.1016/j.immuni.2018.03.002

Mitochondria-ER Pas de Deux Controls Memory T Cell Function

Elizabeth M. Steinert, Navdeep S. Chandel^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Memory CD8⁺ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8⁺ T cells to produce IFN-γ. Memory CD8⁺ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8⁺ T cells to produce IFN-γ.

Original language	English (US)
Pages (from-to)	479-481
Number of pages	3
Journal	Immunity
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2018.03.002
State	Published - Mar 20 2018

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2018.03.002

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title = "Mitochondria-ER Pas de Deux Controls Memory T Cell Function",

abstract = "Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ. Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ.",

author = "Steinert, {Elizabeth M.} and Chandel, {Navdeep S.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

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day = "20",

doi = "10.1016/j.immuni.2018.03.002",

language = "English (US)",

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T1 - Mitochondria-ER Pas de Deux Controls Memory T Cell Function

AU - Steinert, Elizabeth M.

AU - Chandel, Navdeep S.

PY - 2018/3/20

Y1 - 2018/3/20

N2 - Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ. Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ.

AB - Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ. Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ.

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JO - Immunity

JF - Immunity

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ER -

Mitochondria-ER Pas de Deux Controls Memory T Cell Function

Abstract

ASJC Scopus subject areas

UN SDGs

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