Mitochondria-ER Pas de Deux Controls Memory T Cell Function

Elizabeth M. Steinert, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort survey

Abstract

Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ. Memory CD8+ T cells mediate protective secondary immune responses. In this issue, Bantug et al. (2018) demonstrate that mTORC2-AKT-GSK3β signaling at mitochondria-ER contact sites enables the TCA cycle flux that is necessary for memory CD8+ T cells to produce IFN-γ.

Original languageEnglish (US)
Pages (from-to)479-481
Number of pages3
JournalImmunity
Volume48
Issue number3
DOIs
StatePublished - Mar 20 2018

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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