Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases

Jasmine Cisneros, Tayler B. Belton, George C. Shum, Catherine G. Molakal, Yvette C. Wong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Neurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional functions in regulating organelle network dynamics and metabolite transfer between lysosomes and mitochondria. In this review, we highlight recent advances in the field of mitochondria-lysosome contact sites and their misregulation across multiple neurodegenerative disorders, which further underscore a potential role for this pathway in neuronal homeostasis and disease.

Original languageEnglish (US)
Pages (from-to)312-322
Number of pages11
JournalTrends in Neurosciences
Volume45
Issue number4
DOIs
StatePublished - Apr 2022

Keywords

  • Charcot-Marie-Tooth disease
  • inter-organelle contact sites
  • lysosomal storage disorders
  • lysosomes
  • mitochondria
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

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