Mitochondria targeting by environmental stressors: Implications for redox cellular signaling

Chuck Blajszczak, Marcelo G. Bonini*

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that some mitochondria chronically operate at a high ROS baseline. However, it is not completely understood how mitochondria adapt to persistently high ROS states and to environmental stressors that disturb the redox balance. Here we will review some of the current concepts regarding how mitochondria resist oxidative damage, how they are replaced when excessive oxidative damage compromises function, and the effect of environmental toxicants (i.e. heavy metals) on the regulation of mitochondrial ROS (mtROS) production and subsequent impact.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalToxicology
Volume391
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Keywords

  • Arsenic
  • Heavy metals
  • Mitochondria
  • ROS
  • Redox signaling

ASJC Scopus subject areas

  • Toxicology

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