TY - JOUR
T1 - Mitochondrial anchors
T2 - Positioning mitochondria and more
AU - Kraft, Lauren M.
AU - Lackner, Laura L.
N1 - Funding Information:
We thank the members of the Lackner Lab for helpful discussions and comments. We apologize to colleagues whose outstanding work on mitochondrial anchors and positioning could not be including due to space limitations. L.M.K. is supported by the NIH NIGMS Training Grant T32GM008061 . L.L.L is supported by the NIH NIGMS grant R01GM120303 and the Robert H. Lurie Comprehensive Cancer Center – The Lefkofsky Family Foundation /Liz and Eric Lefkofsky Innovation Research Award.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/5/27
Y1 - 2018/5/27
N2 - The shape and position of mitochondria are intimately connected to both mitochondrial and cellular function. Mitochondrial anchors play a central role in mitochondrial positioning by exerting spatial, temporal, and contextual control over the cellular position of the organelle. Investigations into the molecular mechanisms of mitochondrial anchoring are still in the early stages, and we are beginning to appreciate the number and variety of anchors that exist. From the insight gained thus far, it is clear that mitochondrial anchoring has functional and physiological consequences that extend beyond mitochondrial positioning to other critical cellular processes.
AB - The shape and position of mitochondria are intimately connected to both mitochondrial and cellular function. Mitochondrial anchors play a central role in mitochondrial positioning by exerting spatial, temporal, and contextual control over the cellular position of the organelle. Investigations into the molecular mechanisms of mitochondrial anchoring are still in the early stages, and we are beginning to appreciate the number and variety of anchors that exist. From the insight gained thus far, it is clear that mitochondrial anchoring has functional and physiological consequences that extend beyond mitochondrial positioning to other critical cellular processes.
KW - Mitochondrial anchors
KW - Mitochondrial distribution
KW - Mitochondrial positioning
KW - Mitochondrial tethers
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U2 - 10.1016/j.bbrc.2017.06.193
DO - 10.1016/j.bbrc.2017.06.193
M3 - Article
C2 - 28676393
AN - SCOPUS:85021839470
SN - 0006-291X
VL - 500
SP - 2
EP - 8
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -