TY - JOUR
T1 - Mitochondrial complex III
T2 - An essential component of universal oxygen sensing machinery?
AU - Chandel, Navdeep S.
N1 - Funding Information:
This work was supported by a NIH Grant R01CA123067-04 to N.S.C. We thank members of the Chandel lab for critical proofreading. We apologize to those whose important work we could not discuss due to the brevity of this review.
PY - 2010/12/31
Y1 - 2010/12/31
N2 - Oxygen is necessary for the survival of mammalian cells. In order to maintain adequate cellular oxygenation, mammals have evolved multiple acute and long-term adaptive responses to hypoxia. These include hypoxic increases in erythropoiesis, pulmonary vasoconstriction and carotid body neurosecretion. Collectively, these responses help maintain oxygen homeostasis as oxygen levels remain scarce. There are multiple effectors proposed to underlie these diverse responses to hypoxia including PHD2, AMPK, NADPH oxidases, and mitochondrial complex III. Here I propose a model wherein complex III is integral to oxygen sensing in regulating diverse response to hypoxia.
AB - Oxygen is necessary for the survival of mammalian cells. In order to maintain adequate cellular oxygenation, mammals have evolved multiple acute and long-term adaptive responses to hypoxia. These include hypoxic increases in erythropoiesis, pulmonary vasoconstriction and carotid body neurosecretion. Collectively, these responses help maintain oxygen homeostasis as oxygen levels remain scarce. There are multiple effectors proposed to underlie these diverse responses to hypoxia including PHD2, AMPK, NADPH oxidases, and mitochondrial complex III. Here I propose a model wherein complex III is integral to oxygen sensing in regulating diverse response to hypoxia.
KW - Carotid Body
KW - Erythropoiesis
KW - Hypoxia
KW - Pulmonary vasoconstriction
KW - ROS
UR - http://www.scopus.com/inward/record.url?scp=78449283361&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78449283361&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2010.08.004
DO - 10.1016/j.resp.2010.08.004
M3 - Review article
C2 - 20708106
AN - SCOPUS:78449283361
VL - 174
SP - 175
EP - 181
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 3
ER -