Mitochondrial complex III: An essential component of universal oxygen sensing machinery?

Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Oxygen is necessary for the survival of mammalian cells. In order to maintain adequate cellular oxygenation, mammals have evolved multiple acute and long-term adaptive responses to hypoxia. These include hypoxic increases in erythropoiesis, pulmonary vasoconstriction and carotid body neurosecretion. Collectively, these responses help maintain oxygen homeostasis as oxygen levels remain scarce. There are multiple effectors proposed to underlie these diverse responses to hypoxia including PHD2, AMPK, NADPH oxidases, and mitochondrial complex III. Here I propose a model wherein complex III is integral to oxygen sensing in regulating diverse response to hypoxia.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalRespiratory Physiology and Neurobiology
Volume174
Issue number3
DOIs
StatePublished - Dec 31 2010

Keywords

  • Carotid Body
  • Erythropoiesis
  • Hypoxia
  • Pulmonary vasoconstriction
  • ROS

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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