Mitochondrial control of immunity: Beyond ATP

Manan M. Mehta, Samuel E. Weinberg, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

185 Scopus citations

Abstract

Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.

Original languageEnglish (US)
Pages (from-to)608-620
Number of pages13
JournalNature Reviews Immunology
Volume17
Issue number10
DOIs
StatePublished - Oct 1 2017

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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