Mitochondrial control of immunity: Beyond ATP

Manan M. Mehta; Samuel E. Weinberg; Navdeep S. Chandel

doi:10.1038/nri.2017.66

Mitochondrial control of immunity: Beyond ATP

Manan M. Mehta, Samuel E. Weinberg, Navdeep S. Chandel^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

236 Scopus citations

Abstract

Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.

Original language	English (US)
Pages (from-to)	608-620
Number of pages	13
Journal	Nature Reviews Immunology
Volume	17
Issue number	10
DOIs	https://doi.org/10.1038/nri.2017.66
State	Published - Oct 1 2017

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1038/nri.2017.66

Cite this

@article{b83d609719264875b38d3d1cd534f69d,

title = "Mitochondrial control of immunity: Beyond ATP",

abstract = "Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.",

author = "Mehta, {Manan M.} and Weinberg, {Samuel E.} and Chandel, {Navdeep S.}",

note = "Funding Information: This work was supported by the US National Institutes of Health (R35 CA197532, PO1 AG04966502 and PO1 HL071643 to N.S.C.; T32 CA9560 to M.M.M.; and T32 T32HL076139 to S.E.W.). Publisher Copyright: {\textcopyright} 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.",

year = "2017",

month = oct,

day = "1",

doi = "10.1038/nri.2017.66",

language = "English (US)",

volume = "17",

pages = "608--620",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

publisher = "Nature Publishing Group",

number = "10",

}

TY - JOUR

T1 - Mitochondrial control of immunity

T2 - Beyond ATP

AU - Mehta, Manan M.

AU - Weinberg, Samuel E.

AU - Chandel, Navdeep S.

N1 - Funding Information: This work was supported by the US National Institutes of Health (R35 CA197532, PO1 AG04966502 and PO1 HL071643 to N.S.C.; T32 CA9560 to M.M.M.; and T32 T32HL076139 to S.E.W.). Publisher Copyright: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.

AB - Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.

UR - http://www.scopus.com/inward/record.url?scp=85030150492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030150492&partnerID=8YFLogxK

U2 - 10.1038/nri.2017.66

DO - 10.1038/nri.2017.66

M3 - Review article

C2 - 28669986

AN - SCOPUS:85030150492

SN - 1474-1733

VL - 17

SP - 608

EP - 620

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 10

ER -

Mitochondrial control of immunity: Beyond ATP

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this