@article{eb32db98828142e4a28b44e6b4ca330a,
title = "Mitochondrial DNA sequence variants associated with blood pressure among 2 cohorts of older adults",
abstract = "Background-—Age-related changes in blood pressure are associated with a variety of poor health outcomes. Genetic factors are proposed contributors to age-related increases in blood pressure, but few genetic loci have been identified. We examined the role of mitochondrial genomic variation in blood pressure by sequencing the mitochondrial genome. Methods and Results-—Mitochondrial DNA (mtDNA) data from 1755 participants from the LIFE (Lifestyle Interventions and Independence for Elders) studies and 788 participants from the Health ABC (Health, Aging, and Body Composition) study were evaluated using replication analysis followed by meta-analysis. Participants were aged ≥69 years, of diverse racial backgrounds, and assessed for systolic blood pressure (SBP), diastolic blood pressure, and mean arterial pressure. After meta-analysis across the LIFE and Health ABC studies, statistically significant associations of mtDNA variants with higher SBP (m.3197T>C, 16S rRNA; P=0.0005) and mean arterial pressure (m.15924A>G, t-RNA-thr; P=0.004) were identified in white participants. Among black participants, statistically significant associations with higher SBP (m.93A>G, HVII; m.16183A>C, HVI; both P=0.0001) and mean arterial pressure (m.16172T>C, HVI; m.16183A>C, HVI; m.16189T>C, HVI; m.12705C>T; all P{\textquoteright}s<0.0004) were observed. Significant pooled effects on SBP were observed across all transfer RNA regions (P=0.0056) in white participants. The individual and aggregate variant results are statistically significant after multiple comparisons adjustment for the number of mtDNA variants and mitochondrial regions examined. Conclusions-—These results suggest that mtDNA-encoded variants are associated with variation in SBP and mean arterial pressure among older adults. These results may help identify mitochondrial activities to explain differences in blood pressure in older adults and generate new hypotheses surrounding mtDNA variation and the regulation of blood pressure.",
keywords = "Aging, Blood pressure, DNA sequencing, Mitochondria",
author = "Buford, {Thomas W.} and Manini, {Todd M.} and Kairalla, {John A.} and McDermott, {Mary M.} and {Vaz Fragoso}, {Carlos A.} and Haiying Chen and Fielding, {Roger A.} and King, {Abby C.} and Newman, {Anne B.} and Tranah, {Gregory J.}",
note = "Funding Information: Dr. Fielding's contribution is partially supported by the U.S. Department of Agriculture, under agreement No. 58-1950-0-014. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Dept of Agriculture. Funding Information: This research was supported in part by the Intramural Research Program of the National Institutes of Health (NIH), National Institute on Aging, contracts N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106; NIH grants R01-AG028050, R03-AG032498, R01-NR012459, Z01A6000932, and R01-HL121023; and grants from the Research and Education Leadership Committee of the CPMC Foundation and the L. K. Whittier Foundation. The LIFE (Lifestyle Interventions and Independence for Elders) study was also supported by cooperative agreements U01 AG22376, 3U01AG022376-05A2S as well by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (1 P30 AG028740), Tufts University (1P30AG031679), University of Pittsburgh (P30 AG024827), Wake Forest University (P30AG021332), and Yale University (P30AG021342), the NIH/National Center for Research Resources Clinical and Translational Science Award at Stanford University (UL1 RR025744), and the Boston Rehabilitation Outcomes Center (1R24HD065688-01A1) at Tufts University. Dr Fielding{\textquoteright}s work on this project was partially supported by the US Department of Agriculture (USDA), under agreement no. 58-1950-4-003, and the Boston Claude D. Pepper Center Older American Independence Centers (1P30AG031679). Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the USDA. Funding Information: The Pittsburgh Field Center is partially supported by the Pittsburgh Claude D. Pepper Older Americans Independence Center (P30 AG024827). Funding Information: The Wake Forest University Field Center is, in part, supported by the Claude D. Pepper Older Americans Independence Center (1 P30 AG21332). Funding Information: The Lifestyle Interventions and Independence for Elders Study is funded by a National Institutes of Health/National Institute on Aging Cooperative Agreement #UO1 AG22376 and a supplement from the National Heart, Lung and Blood Institute 3U01AG022376-05A2S, and sponsored in part by the Intramural Research Program, National Institute on Aging, NIH. Funding Information: This research is also supported by the Boston Claude D. Pepper Older Americans Independence Center (1P30AG031679) and the Boston Rehabilitation Outcomes Center (1R24HD065688-01A1). Publisher Copyright: {\textcopyright} 2018 The Authors.",
year = "2018",
month = sep,
day = "1",
doi = "10.1161/JAHA.118.010009",
language = "English (US)",
volume = "7",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "18",
}