Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship

Divakar S. Mithal; Navdeep S. Chandel

doi:10.1016/j.molcel.2020.10.002

Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship

Divakar S. Mithal, Navdeep S. Chandel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Recent work by Licznerski et al. suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial membrane proton leak, leading to increased metabolism and changes in protein synthesis that trigger impaired synaptic maturation and autistic behaviors.

Original language	English (US)
Pages (from-to)	381-383
Number of pages	3
Journal	Molecular cell
Volume	80
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2020.10.002
State	Published - Nov 5 2020

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.10.002

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title = "Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship",

abstract = "Recent work by Licznerski et al. suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial membrane proton leak, leading to increased metabolism and changes in protein synthesis that trigger impaired synaptic maturation and autistic behaviors.",

author = "Mithal, {Divakar S.} and Chandel, {Navdeep S.}",

year = "2020",

month = nov,

day = "5",

doi = "10.1016/j.molcel.2020.10.002",

language = "English (US)",

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pages = "381--383",

journal = "Molecular Cell",

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AU - Chandel, Navdeep S.

PY - 2020/11/5

Y1 - 2020/11/5

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AB - Recent work by Licznerski et al. suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial membrane proton leak, leading to increased metabolism and changes in protein synthesis that trigger impaired synaptic maturation and autistic behaviors.

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JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

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Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship

Abstract

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