Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship

Divakar S. Mithal, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Recent work by Licznerski et al. suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial membrane proton leak, leading to increased metabolism and changes in protein synthesis that trigger impaired synaptic maturation and autistic behaviors.

Original languageEnglish (US)
Pages (from-to)381-383
Number of pages3
JournalMolecular cell
Volume80
Issue number3
DOIs
StatePublished - Nov 5 2020

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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