Mitochondrial dysfunction in neurodegenerative diseases and cancer

Michelle Barbide Moura, Lucas Santana Dos Santos, Bennett Van Houten*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

171 Scopus citations

Abstract

Mitochondria are important integrators of cellular function and therefore affect the homeostatic balance of the cell. Besides their important role in producing adenosine triphosphate through oxidative phosphorylation, mitochondria are involved in the control of cytosolic calcium concentration, metabolism of key cellular intermediates, and Fe/S cluster biogenesis and contributed to programmed cell death. Mitochondria are also one of the major cellular producers of reactive oxygen species (ROS). Several human pathologies, including neurodegenerative diseases and cancer, are associated with mitochondrial dysfunction and increased ROS damage. This article reviews how dysfunctional mitochondria contribute to Alzheimer's disease, Parkinson's disease, Huntington's disease, and several human cancers.

Original languageEnglish (US)
Pages (from-to)391-405
Number of pages15
JournalEnvironmental and Molecular Mutagenesis
Volume51
Issue number5
DOIs
StatePublished - Jun 2010
Externally publishedYes

Keywords

  • Cancer
  • Mitochondria
  • Neurodegenerative disease
  • ROS

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

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