Mitochondrial function in sepsis

Nishkantha Arulkumaran, Clifford S. Deutschman, Michael R. Pinsky*, Brian Zuckerbraun, Paul T. Schumacker, Hernando Gomez, Alonso Gomez, Patrick Murray, John A. Kellum

*Corresponding author for this work

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

Mitochondria are an essential part of the cellular infrastructure, being the primary site for high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only common, but also predictive of long-term morbidity and mortality. Clearly, interest is mitochondrial function both as a target for intracellular injury and response to extrinsic stress have been a major focus of basic science and clinical research into the pathophysiology of acute illness. However, mitochondria have multiple metabolic and signaling functions that may be central in both the expression of sepsis and its ultimate outcome. In this review, the authors address five primary questions centered on the role of mitochondria in sepsis. This review should be used both as a summary source in placing mitochondrial physiology within the context of acute illness and as a focal point for addressing new research into diagnostic and treatment opportunities these insights provide.

Original languageEnglish (US)
Pages (from-to)271-281
Number of pages11
JournalShock
Volume45
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Keywords

  • Consensus
  • critical illness
  • mitochondria sepsis

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Arulkumaran, N., Deutschman, C. S., Pinsky, M. R., Zuckerbraun, B., Schumacker, P. T., Gomez, H., ... Kellum, J. A. (2016). Mitochondrial function in sepsis. Shock, 45(3), 271-281. https://doi.org/10.1097/SHK.0000000000000463