Mitochondrial metabolism and cancer

Frank Weinberg, Navdeep S. Chandel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

119 Scopus citations

Abstract

Historically, it has been assumed that glycolytic metabolism, not mitochondrial metabolism, is essential for tumor cell proliferation. However, most tumor cells have functional mitochondria, and recent studies suggest that the citric acid cycle (TCA) cycle intermediates are precursors for synthesis of nucleotides, lipids, and amino acids. Here we review the accumulating evidence that mitochondrial metabolism plays an essential role in tumor cell proliferation.

Original languageEnglish (US)
Title of host publicationHypoxia and Consequences From Molecule to Malady
PublisherBlackwell Publishing Inc.
Pages66-73
Number of pages8
ISBN (Print)9781573317733
DOIs
StatePublished - Jan 1 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1177
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • ATP
  • Glutamine
  • Glycolysis
  • Mitochondria
  • NADPH
  • ROS
  • TCA cycle
  • Warburg effect

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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