Mitochondrial Metabolism as a Target for Cancer Therapy

Karthik Vasan, Marie Werner, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism by providing key metabolites for macromolecule synthesis and generating oncometabolites to maintain the cancer phenotype. Moreover, there are multiple clinical trials testing the efficacy of inhibiting mitochondrial metabolism as a new cancer therapeutic treatment. In this review, we discuss the rationale of using these anti-cancer agents in clinical trials and highlight how to effectively utilize them in different tumor contexts.

Original languageEnglish (US)
Pages (from-to)341-352
Number of pages12
JournalCell Metabolism
Volume32
Issue number3
DOIs
StatePublished - Sep 1 2020

Keywords

  • metformin
  • mitochondria

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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