Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity

Elizabeth M. Steinert, Karthik Vasan, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule synthesis and generating metabolites for T cell function. In this review, we focus on how mitochondrial metabolism controls conventional and regulatory T cell fates and function.

Original languageEnglish (US)
Pages (from-to)395-416
Number of pages22
JournalAnnual Review of Immunology
Volume39
DOIs
StatePublished - Apr 26 2021

Keywords

  • ROS
  • TCA cycle
  • acetyl-CoA
  • epigenetics
  • inflammation
  • l-2-hydroxyglutarate
  • l-2HG

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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