Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity

Elizabeth M. Steinert; Karthik Vasan; Navdeep S. Chandel

doi:10.1146/annurev-immunol-101819-082015

Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity

Elizabeth M. Steinert, Karthik Vasan, Navdeep S. Chandel^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule synthesis and generating metabolites for T cell function. In this review, we focus on how mitochondrial metabolism controls conventional and regulatory T cell fates and function.

Original language	English (US)
Pages (from-to)	395-416
Number of pages	22
Journal	Annual Review of Immunology
Volume	39
DOIs	https://doi.org/10.1146/annurev-immunol-101819-082015
State	Published - Apr 26 2021

Keywords

ROS
TCA cycle
acetyl-CoA
epigenetics
inflammation
l-2-hydroxyglutarate
l-2HG

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1146/annurev-immunol-101819-082015

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title = "Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity",

abstract = "Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule synthesis and generating metabolites for T cell function. In this review, we focus on how mitochondrial metabolism controls conventional and regulatory T cell fates and function.",

keywords = "ROS, TCA cycle, acetyl-CoA, epigenetics, inflammation, l-2-hydroxyglutarate, l-2HG",

author = "Steinert, {Elizabeth M.} and Karthik Vasan and Chandel, {Navdeep S.}",

note = "Funding Information: This work was supported by the NIH (5R35CA197532 and R01AI148190 to N.S.C.), and E.M.S. is a Cancer Research Institute Irvington Fellow supported by the Cancer Research Institute. K.V. is supported by the NIH (5T32CA9560-33, F30CA250236) and Northwestern University Pulmonary and Critical Care Department{\textquoteright}s Cugell Fellowship. Publisher Copyright: {\textcopyright} 2021 Annual Reviews Inc.. All rights reserved.",

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doi = "10.1146/annurev-immunol-101819-082015",

language = "English (US)",

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T1 - Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity

AU - Steinert, Elizabeth M.

AU - Vasan, Karthik

AU - Chandel, Navdeep S.

N1 - Funding Information: This work was supported by the NIH (5R35CA197532 and R01AI148190 to N.S.C.), and E.M.S. is a Cancer Research Institute Irvington Fellow supported by the Cancer Research Institute. K.V. is supported by the NIH (5T32CA9560-33, F30CA250236) and Northwestern University Pulmonary and Critical Care Department’s Cugell Fellowship. Publisher Copyright: © 2021 Annual Reviews Inc.. All rights reserved.

PY - 2021/4/26

Y1 - 2021/4/26

N2 - Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule synthesis and generating metabolites for T cell function. In this review, we focus on how mitochondrial metabolism controls conventional and regulatory T cell fates and function.

AB - Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule synthesis and generating metabolites for T cell function. In this review, we focus on how mitochondrial metabolism controls conventional and regulatory T cell fates and function.

KW - ROS

KW - TCA cycle

KW - acetyl-CoA

KW - epigenetics

KW - inflammation

KW - l-2-hydroxyglutarate

KW - l-2HG

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DO - 10.1146/annurev-immunol-101819-082015

M3 - Review article

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SN - 0732-0582

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EP - 416

JO - Annual Review of Immunology

JF - Annual Review of Immunology

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Mitochondrial Metabolism Regulation of T Cell-Mediated Immunity

Abstract

Keywords

ASJC Scopus subject areas

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