Mitochondrial one-carbon metabolism maintains redox balance during hypoxia

Inmaculada Martínez-Reyes, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Mitochondria generate high levels of reactive oxygen species (ROS) to activate protumorigenic signaling pathways. In parallel, the mitochondria must also increase their antioxidant capacity to lower ROS levels and prevent cancer cell death. In this issue of Cancer Discovery , Ye and colleagues demonstrate that serine catabolism through one-carbon metabolism within the mitochondrial matrix is necessary to maintain this redox balance.

Original languageEnglish (US)
Pages (from-to)1371-1373
Number of pages3
JournalCancer discovery
Issue number12
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Oncology


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