Mitochondrial oxygen sensing: Regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species

Eric L. Bell, Navdeep S. Chandel

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Decreased oxygen availability (hypoxia) promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor HIF (hypoxia-inducible factor). Activation of HIF can also promote pathophysiological processes such as cancer and pulmonary hypertension. The mechanism(s) by which hypoxia activates HIF are the subject of intensive research. In this chapter we outline the model in which mitochondria regulate the stability of HIF through the increased production of ROS (reactive oxygen species) during hypoxia.

Original languageEnglish (US)
Pages (from-to)17-27
Number of pages11
JournalEssays in Biochemistry
Volume43
DOIs
StatePublished - 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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