Mitochondrial regulation of cell survival and death during low-oxygen conditions

Colleen M. Snyder, Navdeep S. Chandel

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Mitochondria can initiate cell death or activate genes that promote cell survival in response to low oxygen. The BCL-2 family of proteins regulate cell death in response to anoxia (0-0.5% O2). By contrast, under hypoxia (0.5-3% O2), mitochondrial oxidative stress activates hypoxia-inducible factors (HIFs) to promote cell survival. In this review, we discuss how mitochondria, BCL-2 proteins, and HIFs are crucial for cellular responses to low oxygen. Antioxid. Redox Signal. 11, 2673-2683.

Original languageEnglish (US)
Pages (from-to)2673-2683
Number of pages11
JournalAntioxidants and Redox Signaling
Issue number11
StatePublished - Nov 1 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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