Mitochondrial regulation of oxygen sensing

Eric L. Bell, Brooke M. Emerling, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations

Abstract

Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.

Original languageEnglish (US)
Pages (from-to)322-332
Number of pages11
JournalMitochondrion
Volume5
Issue number5
DOIs
StatePublished - Oct 1 2005

Keywords

  • Angiogenesis
  • HIF-1
  • Hypoxia
  • Mitochondria
  • Oxygen sensing

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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