Mitochondrial regulation of oxygen sensing

Eric L. Bell; Brooke M. Emerling; Navdeep S. Chandel

doi:10.1016/j.mito.2005.06.005

Mitochondrial regulation of oxygen sensing

Eric L. Bell, Brooke M. Emerling, Navdeep S. Chandel^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

112 Scopus citations

Abstract

Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.

Original language	English (US)
Pages (from-to)	322-332
Number of pages	11
Journal	Mitochondrion
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/j.mito.2005.06.005
State	Published - Oct 2005

Keywords

Angiogenesis
HIF-1
Hypoxia
Mitochondria
Oxygen sensing

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

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10.1016/j.mito.2005.06.005

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title = "Mitochondrial regulation of oxygen sensing",

abstract = "Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.",

keywords = "Angiogenesis, HIF-1, Hypoxia, Mitochondria, Oxygen sensing",

author = "Bell, {Eric L.} and Emerling, {Brooke M.} and Chandel, {Navdeep S.}",

note = "Funding Information: This work was supported by grant NIH grants GM60472-06, P01HL071643-01A4 and American Heart Association grant 0350054N to N.S.C., E.L.B. and B.M.E. are supported by predoctoral training grants T32 CA09560 and T32 HL076139, respectively.",

year = "2005",

month = oct,

doi = "10.1016/j.mito.2005.06.005",

language = "English (US)",

volume = "5",

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journal = "Mitochondrion",

issn = "1567-7249",

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TY - JOUR

T1 - Mitochondrial regulation of oxygen sensing

AU - Bell, Eric L.

AU - Emerling, Brooke M.

AU - Chandel, Navdeep S.

N1 - Funding Information: This work was supported by grant NIH grants GM60472-06, P01HL071643-01A4 and American Heart Association grant 0350054N to N.S.C., E.L.B. and B.M.E. are supported by predoctoral training grants T32 CA09560 and T32 HL076139, respectively.

PY - 2005/10

Y1 - 2005/10

N2 - Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.

AB - Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.

KW - Angiogenesis

KW - HIF-1

KW - Hypoxia

KW - Mitochondria

KW - Oxygen sensing

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DO - 10.1016/j.mito.2005.06.005

M3 - Review article

C2 - 16146708

AN - SCOPUS:26444439977

SN - 1567-7249

VL - 5

SP - 322

EP - 332

JO - Mitochondrion

JF - Mitochondrion

IS - 5

ER -

Mitochondrial regulation of oxygen sensing

Abstract

Keywords

ASJC Scopus subject areas

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