Mitochondrial regulation of oxygen sensing

Navdeep S. Chandel

doi:10.1007/978-1-60761-500-2_22

Mitochondrial regulation of oxygen sensing

Navdeep S. Chandel

Medicine, Pulmonary Division

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

77 Scopus citations

Abstract

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.

Original language	English (US)
Title of host publication	Membrane Receptors, Channels and Transporters in Pulmonary Circulation
Editors	J.X.J Yuan, J.P.T. Ward
Pages	339-354
Number of pages	16
DOIs	https://doi.org/10.1007/978-1-60761-500-2_22
State	Published - 2010

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	661
ISSN (Print)	0065-2598

Funding

This work was supported by grant NIH grants GM60472-06, P01HL071643-01A4 and American Heart Association grant 0350054N to N.S.C., E.L.B. and B.M.E. are supported by predoctoral training grants T32 CA09560 and T32 HL076139, respectively.

Keywords

HIF
Mitochondria
Na/K ATPase
ROS

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-1-60761-500-2_22

Cite this

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title = "Mitochondrial regulation of oxygen sensing",

abstract = "Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.",

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author = "Chandel, {Navdeep S.}",

note = "Funding Information: This work was supported by grant NIH grants GM60472-06, P01HL071643-01A4 and American Heart Association grant 0350054N to N.S.C., E.L.B. and B.M.E. are supported by predoctoral training grants T32 CA09560 and T32 HL076139, respectively. ",

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N2 - Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.

AB - Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.

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KW - Na/K ATPase

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Mitochondrial regulation of oxygen sensing

Abstract

Publication series

Funding

Keywords

ASJC Scopus subject areas

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