Mitochondrial regulation of oxygen sensing

Research output: Chapter in Book/Report/Conference proceedingConference contribution

63 Scopus citations

Abstract

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.

Original languageEnglish (US)
Title of host publicationMembrane Receptors, Channels and Transporters in Pulmonary Circulation
EditorsJ.X.J Yuan, J.P.T. Ward
Pages339-354
Number of pages16
DOIs
StatePublished - 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume661
ISSN (Print)0065-2598

Keywords

  • HIF
  • Mitochondria
  • Na/K ATPase
  • ROS

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Mitochondrial regulation of oxygen sensing'. Together they form a unique fingerprint.

Cite this