Abstract
Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.
Original language | English (US) |
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Pages (from-to) | 1179-1184 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 338 |
Issue number | 2 |
DOIs | |
State | Published - Dec 16 2005 |
Keywords
- Cell cycle
- MRPL41
- Serum starvation
- p21
- p27
- p53
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology