Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1

Mi Jin Kim; Young A. Yoo; Hyung Jung Kim; Seongman Kang; Yong Geon Kim; Jun Suk Kim; Young Do Yoo

doi:10.1016/j.bbrc.2005.10.064

Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21^WAF1/CIP1

Mi Jin Kim, Young A. Yoo, Hyung Jung Kim, Seongman Kang, Yong Geon Kim, Jun Suk Kim, Young Do Yoo^*

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27^Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 ^WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21^WAF1/CIP1 and p27^Kip1 levels under the growth inhibitory conditions.

Original language	English (US)
Pages (from-to)	1179-1184
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	338
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2005.10.064
State	Published - Dec 16 2005

Funding

This research was supported by a grant from the Korean Ministry of Health and Welfare (HMP-02-PJ1-CH03-0001), by a grant from the National Nuclear R&D Program of MOST/KOSEF (M20513000082-05B0900-08200), and by a grant from the Molecular and Cellular BioDiscovery Research Program (M1-0311-00-0035) of MOST/KOSEF.

Keywords

Cell cycle
MRPL41
Serum starvation
p21
p27
p53

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bbrc.2005.10.064

Cite this

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title = "Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1",

abstract = "Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.",

keywords = "Cell cycle, MRPL41, Serum starvation, p21, p27, p53",

author = "Kim, \{Mi Jin\} and Yoo, \{Young A.\} and Kim, \{Hyung Jung\} and Seongman Kang and Kim, \{Yong Geon\} and Kim, \{Jun Suk\} and Yoo, \{Young Do\}",

note = "Funding Information: This research was supported by a grant from the Korean Ministry of Health and Welfare (HMP-02-PJ1-CH03-0001), by a grant from the National Nuclear R\&D Program of MOST/KOSEF (M20513000082-05B0900-08200), and by a grant from the Molecular and Cellular BioDiscovery Research Program (M1-0311-00-0035) of MOST/KOSEF.",

year = "2005",

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doi = "10.1016/j.bbrc.2005.10.064",

language = "English (US)",

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pages = "1179--1184",

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AU - Kim, Mi Jin

AU - Yoo, Young A.

AU - Kim, Hyung Jung

AU - Kang, Seongman

AU - Kim, Yong Geon

AU - Kim, Jun Suk

AU - Yoo, Young Do

N1 - Funding Information: This research was supported by a grant from the Korean Ministry of Health and Welfare (HMP-02-PJ1-CH03-0001), by a grant from the National Nuclear R&D Program of MOST/KOSEF (M20513000082-05B0900-08200), and by a grant from the Molecular and Cellular BioDiscovery Research Program (M1-0311-00-0035) of MOST/KOSEF.

PY - 2005/12/16

Y1 - 2005/12/16

N2 - Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.

AB - Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.

KW - Cell cycle

KW - MRPL41

KW - Serum starvation

KW - p21

KW - p27

KW - p53

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