Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1

Mi Jin Kim, Young A. Yoo, Hyung Jung Kim, Seongman Kang, Yong Geon Kim, Jun Suk Kim, Young Do Yoo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27Kip1 in the absence of p53. This study found that MRPL41 mediates the p21 WAF1/CIP1-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21WAF1/CIP1 and p27Kip1 levels under the growth inhibitory conditions.

Original languageEnglish (US)
Pages (from-to)1179-1184
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume338
Issue number2
DOIs
StatePublished - Dec 16 2005

Keywords

  • Cell cycle
  • MRPL41
  • Serum starvation
  • p21
  • p27
  • p53

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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