Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate

Keyphrases

• Neuronal Dysfunction 100%
• 2-Hydroxyglutarate (2-HG) 100%
• Activating Transcription Factor 4 (ATF4) 100%
• Mitochondrial Stress 100%
• Signaling Mechanism 16%
• Signaling Pathway 16%
• Neurological Diseases 16%
• Overexpressing 16%
• Transcription Factor 16%
• Neuronal Function 16%
• Drosophilidae 16%
• Stress Signaling 16%
• Cellular Metabolism 16%
• Neurological Function 16%
• Cellular Physiology 16%
• Drosophila Brain 16%
• Neuronal Diseases 16%
• Endoplasmic Reticulum Unfolded Protein Response 16%
• Nuclear Gene Expression 16%
• Mitonuclear 16%
• L-2-hydroxyglutarate Dehydrogenase 16%

Biochemistry, Genetics and Molecular Biology

• ATF4 100%
• Signaling Mechanism 33%
• Metabolic Pathway 33%
• Dehydrogenase 33%
• Nuclear Gene 33%
• Gene Expression 33%
• Metabolite 33%
• Unfolded Protein Response 33%
• Activating Transcription Factor 4 33%
• Oxidoreductase 33%
• Stress Signaling 33%

Neuroscience

• ATF4 100%
• Signaling Mechanism 33%
• Nervous System Disorder 33%
• Gene Expression 33%
• Unfolded Protein Response 33%
• Activating Transcription Factor 4 33%
• Metabolic Pathway 33%
• Endoplasmic Reticulum 33%