Mitochondrial Targeting of Probes and Therapeutics to the Powerhouse of the Cell

Cindy Ma, Fan Xia, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Mitochondria, colloquially known as "the powerhouse of the cell", play important roles in production, but also in processes critical for cellular fate such as cell death, differentiation, signaling, metabolic homeostasis, and innate immunity. Due to its many functions in the cell, the mitochondria have been linked to a variety of human illnesses such as diabetes, cancer, and neurodegenerative diseases. In order to further our understanding and pharmaceutical targeting of this critical organelle, effective strategies must be employed to breach the complex barriers and microenvironment of mitochondria. Here, we summarize advancements in mitochondria-targeted probes and therapeutics.

Original languageEnglish (US)
Pages (from-to)2650-2667
Number of pages18
JournalBioconjugate Chemistry
Issue number12
StatePublished - Dec 16 2020
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


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