Mitogenic effect in mouse liver induced by a hypolipidemic drug, nafenopin

David E. Moody, M. Sambasiva Rao, Janardan K. Reddy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

The mitogenic effect of Nafenopin, a hypolipidemic hepatic peroxisome proliferator, in mouse liver has been studied in acute and chronically treated mice. After 1, 6 and 32 weeks of treatment, the total hepatic DNA was increased 1.5-2.0-fold over controls. Mitotic and labeling indices were also increased 3-4 fold after 5 days, 6 weeks and 32 weeks of treatment. The increased mitotic activity in nafenopin fed animals was not associated with liver cell necrosis. The nafenopin induced hepatomegaly therefore appears to arise from a combination of cell proliferation, as well as, cellular hypertrophy, which is associated with peroxisome proliferation.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalVirchows Archiv B Cell Pathology
Volume23
Issue number1
DOIs
StatePublished - Dec 1 1977

Keywords

  • Mitogenic effect
  • Nafenopin
  • Peroxisomes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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