Mixed pineal mature teratoma and germinoma in two brothers of the fraternal triplets

Gordan Grahovac*, Tord D Alden, Nitin Ramesh Wadhwani

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Introduction: Intracranial teratomas are rare germ cell neoplasms that contain tissues derived from all three germ cell layers and most commonly occurring during childhood. This is the first report of pineal region mixed mature teratoma and germinoma in two fraternal brothers of fraternal triplets. Case presentation: We report the case of a mixed mature teratoma and germinoma of the pineal region in two brothers of fraternal triplets. Older brother was initially diagnosed at the age of 11 years with the pure teratoma of the pineal region but the review of the pathology 3 years after initial surgery revealed the mixed mature teratoma with 5% germinomatous component. The younger brother was diagnosed at the age of 13 years with the mixed mature teratoma with 10% germinomatous component tumor of the pineal region. Younger brother has been treated with adjuvant chemo-radiotherapy and older brother was treated without adjuvant therapy. Both brothers had no recurrence. Conclusion: Pineal mature teratomas have a good prognosis, in contrast to their immature or mixed counterparts. A rigorous histological examination of the tumor samples is mandatory, in order to not omit a mixed contingent within the tumor.

Original languageEnglish (US)
Pages (from-to)859-863
Number of pages5
JournalChild's Nervous System
Volume33
Issue number5
DOIs
StatePublished - May 1 2017

Keywords

  • Brain tumors
  • Germinoma
  • Pineal tumors
  • Teratoma
  • Twins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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