Mixture-based Multiple Imputation Model for Clinical Data with a Temporal Dimension

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The problem of missing values in multivariable time series is a key challenge in many applications such as clinical data mining. Although many imputation methods show their effectiveness in many applications, few of them are designed to accommodate clinical multivariable time series. In this work, we propose a multiple imputation model that capture both cross-sectional information and temporal correlations. We integrate Gaussian processes with mixture models and introduce individualized mixing weights to handle the variance of predictive confidence of Gaussian process models. The proposed model is compared with several state-of-the-art imputation algorithms on both real-world and synthetic datasets. Experiments show that our best model can provide more accurate imputation than the benchmarks on all of our datasets.

Original languageEnglish (US)
Title of host publicationProceedings - 2019 IEEE International Conference on Big Data, Big Data 2019
EditorsChaitanya Baru, Jun Huan, Latifur Khan, Xiaohua Tony Hu, Ronay Ak, Yuanyuan Tian, Roger Barga, Carlo Zaniolo, Kisung Lee, Yanfang Fanny Ye
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages245-252
Number of pages8
ISBN (Electronic)9781728108582
DOIs
StatePublished - Dec 2019
Event2019 IEEE International Conference on Big Data, Big Data 2019 - Los Angeles, United States
Duration: Dec 9 2019Dec 12 2019

Publication series

NameProceedings - 2019 IEEE International Conference on Big Data, Big Data 2019

Conference

Conference2019 IEEE International Conference on Big Data, Big Data 2019
CountryUnited States
CityLos Angeles
Period12/9/1912/12/19

Keywords

  • data mining
  • EHR
  • Gaussian process
  • Imputation
  • missing data

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Networks and Communications
  • Information Systems
  • Information Systems and Management

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  • Cite this

    Xue, Y., Klabjan, D., & Luo, Y. (2019). Mixture-based Multiple Imputation Model for Clinical Data with a Temporal Dimension. In C. Baru, J. Huan, L. Khan, X. T. Hu, R. Ak, Y. Tian, R. Barga, C. Zaniolo, K. Lee, & Y. F. Ye (Eds.), Proceedings - 2019 IEEE International Conference on Big Data, Big Data 2019 (pp. 245-252). [9005672] (Proceedings - 2019 IEEE International Conference on Big Data, Big Data 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BigData47090.2019.9005672