MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

Keyphrases

• Tight 100%
• Intestinal Epithelial Cells 100%
• Kinase Cascade 100%
• Matrix metalloproteinase-9 (MMP-9) 100%
• Myosin Light Chain Kinase 100%
• P38 MAP Kinase 100%
• Signaling Pathway Activation 100%
• Intestinal Tight Junction 35%
• Inflammatory Bowel Disease 29%
• Intestinal Permeability 23%
• Tight Junction 17%
• Tight Junction Barrier 17%
• Caco-2 17%
• Gene Activity 17%
• Protein Expression 11%
• Intestinal Inflammation 11%
• Gene Expression 5%
• Signal Transduction Pathway 5%
• Intracellular Signaling 5%
• Therapeutic Targeting 5%
• Endothelial Junctions 5%
• Barrier Function 5%
• Enzymatic Activity 5%
• Small Interfering RNA (siRNA) 5%
• Knockdown 5%
• Kinase Activity 5%
• Intestinal Barrier Function 5%
• Intestinal Tissue 5%
• In Vivo Mice 5%
• Kinase Inhibition 5%
• Expression Activity 5%
• Gene-deficient Mice 5%
• Dose Effect 5%
• Perfusion System 5%
• Pathogenic Factors 5%
• Matrix Effect 5%
• Mouse Intestine 5%
• Fast Activation 5%
• Intestinal Epithelial Barrier Function 5%
• Caco-2 Cell Monolayer 5%

Biochemistry, Genetics and Molecular Biology

• Signal Transduction 100%
• Kinase 100%
• Phosphotransferase 100%
• Gelatinase B 100%
• MMP9 100%
• Myosin Light-Chain Kinase 100%
• Gene Activity 17%
• Protein Expression 11%
• Small Interfering RNA 5%
• Small Intestine 5%
• Intestinal Mucosal Barrier 5%
• Gene Expression 5%
• Enzyme Activity 5%
• Perfusion 5%
• Upregulation 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Phosphotransferase 100%
• Gelatinase B 100%
• Myosin Light Chain Kinase 100%
• Inflammatory Bowel Disease 29%
• Intestinal Permeability 23%
• Enteritis 11%
• Small Interfering RNA 5%