MMPI measures of impulsivity and depression correlate with CSF 5-HIAA and HVA in depression but not schizophrenia

William O. Faustman; Roy J. King; Kym F. Faull; James A. Moses; Kathleen L. Benson; Vincent P. Zarcone; John G. Csernansky

doi:10.1016/0165-0327(91)90069-5

MMPI measures of impulsivity and depression correlate with CSF 5-HIAA and HVA in depression but not schizophrenia

William O. Faustman^*, Roy J. King, Kym F. Faull, James A. Moses, Kathleen L. Benson, Vincent P. Zarcone, John G. Csernansky

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Recent studies have linked impulsivity with CSF concentrations of both 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA). One work found a negative correlation between the MMPI psychopathic deviate (Pd) scale and 5-HIAA in personality disordered men (Brown et al., 1982). We found that the 5-HIAA/Pd correlation extends (P < 0.05) to unmedicated depressed patients (n = 21). A trend was found between HVA and Pd in depression. There was no relationship between either metabolite and the Pd scale in unmedicated schizophrenics (n = 24). A significant inverse correlation was found between the MMPI depression scale and CSF HVA but not 5-HIAA in the depressed patients.

Original language	English (US)
Pages (from-to)	235-239
Number of pages	5
Journal	Journal of Affective Disorders
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/0165-0327(91)90069-5
State	Published - Aug 1991

Keywords

CSF 5-HIAA
CSF HVA
Depression
Impulsivity
MMPI
Schizophrenia

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-0327(91)90069-5

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@article{9032b056835e4268af8b966e0e2b0159,

title = "MMPI measures of impulsivity and depression correlate with CSF 5-HIAA and HVA in depression but not schizophrenia",

abstract = "Recent studies have linked impulsivity with CSF concentrations of both 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA). One work found a negative correlation between the MMPI psychopathic deviate (Pd) scale and 5-HIAA in personality disordered men (Brown et al., 1982). We found that the 5-HIAA/Pd correlation extends (P < 0.05) to unmedicated depressed patients (n = 21). A trend was found between HVA and Pd in depression. There was no relationship between either metabolite and the Pd scale in unmedicated schizophrenics (n = 24). A significant inverse correlation was found between the MMPI depression scale and CSF HVA but not 5-HIAA in the depressed patients.",

keywords = "CSF 5-HIAA, CSF HVA, Depression, Impulsivity, MMPI, Schizophrenia",

author = "Faustman, {William O.} and King, {Roy J.} and Faull, {Kym F.} and Moses, {James A.} and Benson, {Kathleen L.} and Zarcone, {Vincent P.} and Csernansky, {John G.}",

note = "Funding Information: Supported by MH30854 to the Stanford/VA Mental Health Clinical Reseach Center and research funds from the Department of Veterans Affairs.",

year = "1991",

month = aug,

doi = "10.1016/0165-0327(91)90069-5",

language = "English (US)",

volume = "22",

pages = "235--239",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

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TY - JOUR

T1 - MMPI measures of impulsivity and depression correlate with CSF 5-HIAA and HVA in depression but not schizophrenia

AU - Faustman, William O.

AU - King, Roy J.

AU - Faull, Kym F.

AU - Moses, James A.

AU - Benson, Kathleen L.

AU - Zarcone, Vincent P.

AU - Csernansky, John G.

N1 - Funding Information: Supported by MH30854 to the Stanford/VA Mental Health Clinical Reseach Center and research funds from the Department of Veterans Affairs.

PY - 1991/8

Y1 - 1991/8

N2 - Recent studies have linked impulsivity with CSF concentrations of both 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA). One work found a negative correlation between the MMPI psychopathic deviate (Pd) scale and 5-HIAA in personality disordered men (Brown et al., 1982). We found that the 5-HIAA/Pd correlation extends (P < 0.05) to unmedicated depressed patients (n = 21). A trend was found between HVA and Pd in depression. There was no relationship between either metabolite and the Pd scale in unmedicated schizophrenics (n = 24). A significant inverse correlation was found between the MMPI depression scale and CSF HVA but not 5-HIAA in the depressed patients.

AB - Recent studies have linked impulsivity with CSF concentrations of both 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA). One work found a negative correlation between the MMPI psychopathic deviate (Pd) scale and 5-HIAA in personality disordered men (Brown et al., 1982). We found that the 5-HIAA/Pd correlation extends (P < 0.05) to unmedicated depressed patients (n = 21). A trend was found between HVA and Pd in depression. There was no relationship between either metabolite and the Pd scale in unmedicated schizophrenics (n = 24). A significant inverse correlation was found between the MMPI depression scale and CSF HVA but not 5-HIAA in the depressed patients.

KW - CSF 5-HIAA

KW - CSF HVA

KW - Depression

KW - Impulsivity

KW - MMPI

KW - Schizophrenia

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U2 - 10.1016/0165-0327(91)90069-5

DO - 10.1016/0165-0327(91)90069-5

M3 - Article

C2 - 1939932

AN - SCOPUS:0025738989

SN - 0165-0327

VL - 22

SP - 235

EP - 239

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 4

ER -

MMPI measures of impulsivity and depression correlate with CSF 5-HIAA and HVA in depression but not schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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