MMPI measures of impulsivity and depression correlate with CSF 5-HIAA and HVA in depression but not schizophrenia

William O. Faustman*, Roy J. King, Kym F. Faull, James A. Moses, Kathleen L. Benson, Vincent P. Zarcone, John G. Csernansky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Recent studies have linked impulsivity with CSF concentrations of both 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA). One work found a negative correlation between the MMPI psychopathic deviate (Pd) scale and 5-HIAA in personality disordered men (Brown et al., 1982). We found that the 5-HIAA/Pd correlation extends (P < 0.05) to unmedicated depressed patients (n = 21). A trend was found between HVA and Pd in depression. There was no relationship between either metabolite and the Pd scale in unmedicated schizophrenics (n = 24). A significant inverse correlation was found between the MMPI depression scale and CSF HVA but not 5-HIAA in the depressed patients.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalJournal of Affective Disorders
Volume22
Issue number4
DOIs
StatePublished - Aug 1991

Keywords

  • CSF 5-HIAA
  • CSF HVA
  • Depression
  • Impulsivity
  • MMPI
  • Schizophrenia

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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