Mode of Ascertainment is Critical in Assessing Safety of Percutaneous Umbilical Blood Sampling

L. P. Shulman, M. L. Moretti, A. T. Tharapel, D. C. Shaver, B. M. Mercer, B. M. Sibai, C. M. Meyers, O. P. Phillips, J. V. Dacus, J. R. Barton, J. L. Simpson, S. Elias

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Percutaneous umbilical blood sampling (PUBS) is increasingly utilized for cytogene-tic assessment of the fetus. In the present study, outcome of 109 PUBS-derived fetal blood samples were analyzed according to mode of ascertainment: ultrasound-detected anatomic anomalies or intrauterine growth retardation (IUGR). Abnormal chromosome complements were found in 6 of 47 (12.8%) fetuses with anomalies but in only 1 of 62 (1.6%) fetuses with IUGR alone. Perinatal loss in fetuses with anatomic anomalies was 64.4%, compared with only 1.6% in fetuses with IUGR alone. Mode of patient ascertainment is an important factor that must be considered in determining procedure-related risks for PUBS.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalAmerican journal of perinatology
Volume10
Issue number1
DOIs
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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