Model-free deconvolution techniques for estimating vascular transport functions

Thomas A. Bronikowski*, Christopher A. Dawson, John H. Linehan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


In this paper we present two methods which can be used to numerically deconvolve indicator dilution curves to obtain vascular transport functions. In the first method, direct algebraic deconvolution is made stable and practical by the damped least squares method. The second method involves a time-shift of the output curve which is based on the first and second moments of the input and output curves. This method is stable, computationally simple and can provide reasonable estimates of the transport function.

Original languageEnglish (US)
Pages (from-to)411-429
Number of pages19
JournalInternational Journal of Bio-Medical Computing
Issue number5
StatePublished - Sep 1983

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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