Model of topographic map development guided by a transiently expressed repulsion molecule

Sherwin E. Hua*, Lina L. Massone, James Charles Houk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The projection from the retina develops into a precise map of the visual world on the surface of the tectum. The search for molecular position cues that mediate map formation has recently yielded a tectal molecule that exerts a repulsion to fibers from the entire temporal half retina. This molecule appears not to function in the generally accepted gradient manner but instead provides only binary position information, and it is only expressed transiently during early development. Here we describe modeling results that compare the efficacy of binary versus graded position cues in topographic map formation; the model also includes an activity dependent process. We find that binary repulsion is more efficient than graded chemo-affinity in the rapid establishment of map polarity, and transient expression of either cue provides sufficient guidance for precise map formation.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalNeuroReport
Volume4
Issue number12
DOIs
StatePublished - Jan 1 1993

Keywords

  • Computer simulation
  • Gradient
  • Map
  • Neural network
  • Polarity
  • Position cues
  • Retina
  • Tectum
  • Topography

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Model of topographic map development guided by a transiently expressed repulsion molecule'. Together they form a unique fingerprint.

Cite this