Model Studies for Coenzyme B12 Dependent Enzyme-Catalyzed Rearrangements. Evidence for Cobalt(III)-Olefin π Complexes

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Methanolysis of 2-acetoxyethyl-2-13C-(pyridine)cobaloxime gave equal amounts of methoxyethyl-l- 13C- and -2- 13C-(pyridine)cobaloxime. This shows that during the solvolysis both carbon atoms, of the ligand bonded to cobalt, became equivalent, and the intermediate for this can be envisaged as an olefin π complex of cobalt. Further evidence for olefin complexes of trivalent cobalt was obtained from the reaction between cob(III)alamins or cob(III)aloximes and vinyl ethers which gave the corresponding σ-bonded cobalt acetals. By involving such π complexes as intermediates of the reactions which are catalyzed by the B12 coenzyme, one can account for, and generalize, the overall enzymatic rearrangements.

Original languageEnglish (US)
Pages (from-to)4626-4633
Number of pages8
JournalJournal of the American Chemical Society
Volume98
Issue number15
DOIs
StatePublished - Jul 1 1976

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint

Dive into the research topics of 'Model Studies for Coenzyme B12 Dependent Enzyme-Catalyzed Rearrangements. Evidence for Cobalt(III)-Olefin π Complexes'. Together they form a unique fingerprint.

Cite this