Modeling adult gliomas using RCAS/t-va technology

Dolores Hambardzumyan*, Nduka M. Amankulor, Karim Y. Helmy, Oren J. Becher, Eric C. Holland

*Corresponding author for this work

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

Malignant gliomas remain the most devastating childhood and adult tumors of the central nervous system. Although adult and pediatric gliomas are histologically indistinguishable, they differ in location, behavior, and molecular characteristics. This implies that the molecular pathways and pathophysiology of malignant gliomagenesis in these two populations are distinct. Such differences between adult and pediatric gliomas may predict different therapeutic responses. Therefore, accurate genetically engineered models of adult and pediatric gliomas may help understand the biology of these tumors and evaluate therapeutic agents in preclinical studies. It has been proposed that gliomas arise from the subventricular zone in mice during development. Here, we demonstrate that, in adult mice, gliomas may arise not only when injected in the subventricular zone but also when injected in the cortex and cerebellum. Our work demonstrates a versatile and highly reproducible adult mouse model of glioma, which can be easily incorporated into preclinical studies.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalTranslational Oncology
Volume2
Issue number2
DOIs
StatePublished - Jun 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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