Modeling adult gliomas using RCAS/t-va technology

Dolores Hambardzumyan*, Nduka M. Amankulor, Karim Y. Helmy, Oren J. Becher, Eric C. Holland

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

212 Scopus citations

Abstract

Malignant gliomas remain the most devastating childhood and adult tumors of the central nervous system. Although adult and pediatric gliomas are histologically indistinguishable, they differ in location, behavior, and molecular characteristics. This implies that the molecular pathways and pathophysiology of malignant gliomagenesis in these two populations are distinct. Such differences between adult and pediatric gliomas may predict different therapeutic responses. Therefore, accurate genetically engineered models of adult and pediatric gliomas may help understand the biology of these tumors and evaluate therapeutic agents in preclinical studies. It has been proposed that gliomas arise from the subventricular zone in mice during development. Here, we demonstrate that, in adult mice, gliomas may arise not only when injected in the subventricular zone but also when injected in the cortex and cerebellum. Our work demonstrates a versatile and highly reproducible adult mouse model of glioma, which can be easily incorporated into preclinical studies.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalTranslational Oncology
Volume2
Issue number2
DOIs
StatePublished - Jun 2009

Funding

Address all correspondence to: Eric Holland or Dolores Hambardzumyan, 1275 York Ave, New York, NY 10021. E-mail: [email protected], [email protected] 1This work was supported by Brain Tumor Center. K.Y.H. is a Howard Hughes Medical Institute Medical Research Training Fellow. 2This article refers to supplementary materials, which are designated by Figures W1 and W2 and are available online at www.transonc.com. 3These authors contributed equally to this work. Received 13 January 2009; Revised 13 January 2009; Accepted 14 January 2009 Copyright © 2009 Neoplasia Press, Inc. Open access under CC BY-NC-ND license. 1944-7124 DOI 10.1593/tlo.09100

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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