Modeling ex vivo hematopoiesis using chemical engineering metaphors

L. K. Nielsen*, E. T. Papoutsakis, W. M. Miller

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Ex vivo hematopoiesis is increasingly used for clinical applications. Models of ex vivo hematopoiesis are required to better understand the complex dynamics and to optimize hematopoietic culture processes. A general mathematical modeling framework is developed which uses traditional chemical engineering metaphors to describe the complex hematopoietic dynamics. Tanks and tubular reactors are used to describe the (pseudo-) stochastic and deterministic elements of hematopoiesis, respectively. Cells at any point in the differentiation process can belong to either an immobilized, inert phase (quiescent cells) or a mobile, active phase (cycling cells). The model describes five processes: (1) flow (differentiation), (2) autocatalytic formation (growth), (3) degradation (death), (4) phase transition from immobilized to mobile phase (quiescent to cycling transition), and (5) phase transition from mobile to immobilized phase (cycling to quiescent transition). The modeling framework is illustrated with an example concerning the effect of TGF-β1 on erythropoiesis.

Original languageEnglish (US)
Pages (from-to)1913-1925
Number of pages13
JournalChemical Engineering Science
Volume53
Issue number10
DOIs
StatePublished - May 15 1998

Keywords

  • Differentiation
  • Erythropoiesis
  • Hematopoiesis
  • Mathematical model
  • TGF-β1

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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