Modeling human influenza infection in the laboratory

Kathryn A. Radigan*, Alexander V. Misharin, Monica Chi, G. R.Scott Budinger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Influenza is the leading cause of death from an infectious cause. Because of its clinical importance, many investigators use animal models to understand the biologic mechanisms of influenza A virus replication, the immune response to the virus, and the efficacy of novel therapies. This review will focus on the biosafety, biosecurity, and ethical concerns that must be considered in pursuing influenza research, in addition to focusing on the two animal models – mice and ferrets – most frequently used by researchers as models of human influenza infection.

Original languageEnglish (US)
Pages (from-to)311-320
Number of pages10
JournalInfection and Drug Resistance
Volume8
DOIs
StatePublished - Aug 31 2015

Keywords

  • Animal model
  • Biosafety
  • Ferret
  • Influenza
  • Mice

ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

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