Modeling learning in brain stem and cerebellar sites responsible for VOR plasticity

Kevin J. Quinn, Allan J. Didier, James F. Baker*, Barry W. Peterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A simple model of vestibuloocular reflex (VOR) function was used to analyze several hypotheses currently held concerning the characteristics of VOR plasticity. The network included a direct vestibular pathway and an indirect path via the cerebellum. An optimization analysis of this model suggests that regulation of brain stem sites is critical for the proper modification of VOR gain. A more physiologically plausible learning rule was also applied to this network. Analysis of these simulation results suggests that the preferred error correction signal controlling gain modification of the VOR is the direct output of the accessory optic system (AOS) to the vestibular nuclei vs. a signal relayed through the cerebellum via floccular Purkinje cells. The potential anatomical and physiological basis for this conclusion is discussed, in relation to our current understanding of the latency of the adapted VOR response.

Original languageEnglish (US)
Pages (from-to)333-346
Number of pages14
JournalBrain Research Bulletin
Volume46
Issue number4
DOIs
StatePublished - Jul 1 1998

Keywords

  • Adaptation
  • Brain stem
  • Cerebellum
  • Modeling
  • Vestibuloocular reflex

ASJC Scopus subject areas

  • Neuroscience(all)

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