TY - JOUR
T1 - Modeling stochastic spike train responses of neurons
T2 - An extended Wiener series analysis of pigeon auditory nerve fibers
AU - Joeken, Stephan
AU - Schwegler, Helmut
AU - Richter, Claus Peter
PY - 1997
Y1 - 1997
N2 - A general method for developing data-based, stochastic nonlinear models of neurons by means of extended functional series expansions was applied to neural activities of pigeon auditory nerve fibers responding to Gaussian white noise stimuli. To determine Wiener series representations of the investigated neurons the fast orthogonal search algorithm was used. The results suggest that nonlinearities are only instantaneous and that the signal transduction of the investigated sensory system can be described by cascades of dynamic linear and static nonlinear devices. However, only slight improvements result from the nonlinear terms. Considerable improvements are, nevertheless, possible by generalizing the ordinary Wiener series, so that prior neural activity can be taken into account. These extended series were used to develop stochastic models of spiking neurons. The models are able to generate realistic interspike interval distributions and rate-intensity functions. Finally, it will be shown that the irregularity in real and modeled action potential trains has advantages concerning the decoding of neural responses.
AB - A general method for developing data-based, stochastic nonlinear models of neurons by means of extended functional series expansions was applied to neural activities of pigeon auditory nerve fibers responding to Gaussian white noise stimuli. To determine Wiener series representations of the investigated neurons the fast orthogonal search algorithm was used. The results suggest that nonlinearities are only instantaneous and that the signal transduction of the investigated sensory system can be described by cascades of dynamic linear and static nonlinear devices. However, only slight improvements result from the nonlinear terms. Considerable improvements are, nevertheless, possible by generalizing the ordinary Wiener series, so that prior neural activity can be taken into account. These extended series were used to develop stochastic models of spiking neurons. The models are able to generate realistic interspike interval distributions and rate-intensity functions. Finally, it will be shown that the irregularity in real and modeled action potential trains has advantages concerning the decoding of neural responses.
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U2 - 10.1007/s004220050328
DO - 10.1007/s004220050328
M3 - Article
C2 - 9116078
AN - SCOPUS:0031064259
SN - 0340-1200
VL - 76
SP - 153
EP - 162
JO - Biological Cybernetics
JF - Biological Cybernetics
IS - 2
ER -