Modeling the cochlear microphonic in prestin knockout mice

Mary Ann Cheatham, K. Naik, J. Siegel, Peter Dallos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Based on the assumption that individual hair-cell current contributions are proportional to local basilar-membrane amplitude and phase, a model simulating the cochlear microphonic (CM) measured at the round window in mice was constructed, similar to what others have done [1, 2] for Guinea pig. Hair-cell contributions were vectorially summed along the length of the cochlear partition. Due to rapidly changing phase in the amplified tip region of the traveling wave, this segment contributes negligibly to the summed response, except at very high frequencies. As a result, the CM is usually dominated by hair-cell outputs on the mechanically linear tails of the traveling wave, i.e., the CM reflects passive cochlear responses. The CM recorded at the round window from mice lacking prestin is consistent with model predictions. Hence, the CM is not a good metric to assay integrity of the cochlear amplifier.

Original languageEnglish (US)
Title of host publicationConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008
EditorsDavid T. Kemp, Nigel P. Cooper
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages371-376
Number of pages6
ISBN (Electronic)9789812833778
StatePublished - Jan 1 2008
Event10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008 - Newcastle, United Kingdom
Duration: Jul 27 2008Jul 31 2008

Publication series

NameConcepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008

Conference

Conference10th International Workshop on the Mechanics of Hearing - Concepts and Challenges in the Biophysics of Hearing, MoH 2008
CountryUnited Kingdom
CityNewcastle
Period7/27/087/31/08

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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  • Cite this

    Cheatham, M. A., Naik, K., Siegel, J., & Dallos, P. (2008). Modeling the cochlear microphonic in prestin knockout mice. In D. T. Kemp, & N. P. Cooper (Eds.), Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008 (pp. 371-376). (Concepts and Challenges in the Biophysics of Hearing - Proceedings of the 10th International Workshop on the Mechanics of Hearing, MoH 2008). World Scientific Publishing Co. Pte Ltd.